Polymyalgia Rheumatica, an Age-Related Rheumatic Disease

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to high-grade systemic inflammation, it characterized by typical “polymyalgic” musculoskeletal symptoms, including diffuse and severe pain prolonged morning stiffness of shoulder girdle, pelvic neck. PMR a member so-called giant cell arteritis complex; however, in spite marked inflammation PMR, local vasculitis process aborts. The pathological background synovitis, predominant extra-articular synovial structures. Synovitis mild, transient, non-erosive. Distal symptoms are also observed but more variable less recognizable than proximal polymyalgic syndrome. often overlaps elderly-onset seronegative arthritides, rheumatoid arthritis, late-onset spondylarthritis, RS3PE1 Although glucocorticoids cornerstone therapy, considerable hope attached tocilizumab, IL-6 receptor inhibitor.